Abstract

NANOEMULGEL: A NOVEL FORMULATION APPROACH FOR TOPICAL DELIVEREY OF HYDROPHOBIC DRUGS

Kalpana Basera*, Ganesh Bhatt, Preeti Kothiyal and Pooja Gupta

ABSTRACT

The advances in knowledge about production and stability of dispersed systems enable the development of differentiated vehicles such as nanoemulsion and nanoemulgel. Dermatological products applied to skin are diverse in formulation and range in consistency from liquids to powder but the most popular products are semisolid preparations .Topical gel are transparent or translucent semisolid formulation and used for the localized drug delivery anywhere in the body through rectal, vaginal, ophthalmic and skin as topical route. Gel formulation provides better application property and stability in comparision of ointment and cream. Nanoemulgel has emerged as one of the most interesting topical delivery system as it has dual release control system i.e. Hydrogel and nanoemulsion. Nanoemulgel having nanosize (10 -100μm) rapidly penetrates and deliver active substance deeper and quicker. The use of emulgels can be considered well in analgesics and antifungal drugs. In recent year there has been great interest in the use of novel polymer with complex function such as emulsifiers and thickeners. The gelling capacity of this compound allows the formulation of stable emulsion and creams by decreasing surface and interfacial tension at the same time increasing the viscosity of aqueous phase. In spite of many advantage of gels a major limitation is in the delivery of hydrophobic drug. So to overcome this limitation an emulsion based approach is being used to that even a hydrophobic moiety can enjoy the unique property of gel.

Keywords: Nanoemulgel, Nanoemulsion, Hydrogel, Skin, Hydrophobic Drugs.