Abstract

CHANGES IN BLOOD COUNT ASSOCIATED WITH MULTIPLE DRUG ADMINISTRATION IN RABBIT

Afshan Siddiq* and Rafeeq Alam Khan

ABSTRACT

Hematological toxicities are very common and associated with the prolong use of drugs. The present study is performed to evaluate the comparison of individual drugs and cumulative effect of combinations of drugs on hematological parameters. These drugs are usually prescribed for the treatment of multiple disorders including hypertension, hyperlipidemia and hyperglycemia. In the present study, individual as well as different combinations of the drugs are given to the rabbits for the period 60 days. Blood samples were taken at the end of study to evaluate red blood cell count (RBC), white blood cell count (WBC), platelets and hemoglobin percentage. The results showed no any change in RBCs and hemoglobin percentage. However, as compared to control rabbits, Glibenclamide, Metformin, Lisinopril individually as well as those received combinations of Glibenclamide, Losartin and Atorvastatin and Metformin, Amliodepine and Atorvastatin decreased platelets count (P<0.05) while Amlodipine increased it (P<0.05).Glibenclamide and combinations of Glibenclamide, Losartan and Atorvastatin and Metformin, Amlodipine and Atorvastatin decreased WBCs (P<0.05).

Keywords: Hematological toxicities, hyperlipidemia, hypoglycemia, hypertension, platelets, white blood cells and red blood cells.