Abstract

NANOTECHNOLOGY- ADVANCE PROGRESS FOR TARGETED THERAPY IN CANCER

Reena Singh¹*, S.K. Prajapati1, Rizwana khan¹

Institute of Pharmacy, Bundelkhand University Jhansi, U.P India-284128.

ABSTRACT

Advance developments of nanotechnology offer to significantly transform cancer therapeutics. Cancer nanotechnology which is an interdisciplinary research, cutting across the disciplines of biology, chemistry, engineering, physics & medicine is superior to surgery, radiation treatments, chemotherapeutic agents, photodynamic therapy, hormonal treatments and angiogenesis. Targeted delivery of drug molecules to tumor tissue is one of the most interesting and challenging endeavors face pharmaceutical field, due to the critical and pharmacokinetically specific environment that exists in tumor. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nano devices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumorspecific proteins both on the surface of and inside cancer cells. The Nonspecific drug delivery leads to significant complications that represent a serious obstacle to effective anticancer therapy. This review discusses the use of nanoparticles such as liposome, polymer, quantum dots, solid-lipid nanoparticles, nanoshells, and dendrimers etc. for the detection and treatment of cancer.

Keywords: Nanotechnology, Cancer therapy, Dendrimer, Quantam dots.