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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

ROLE OF VENLAFAXINE AND DEXIBUPROFEN IN A NEW RAT MODEL OF CHRONIC PAIN INDUCED DEPRESSION THROUGH MONOSODIUM IODO ACETATE (MIA) INDUCED OSTEOARTHRITIS IN RATS

V.S.Saravanan*¹ ,V.Krishnaraju ²

¹HOD, Pharamaceutical Analysis, Erode College of Pharmacy, India.

²Research scholar, Erode College of Pharmacy, India.

ABSTRACT

Objective: To understand the role of Venlafaxine and Dexibuprofen in a new single rat model of chronic pain and pain induced depression. Methods: Twenty four male wistar rats were divided into 4 groups of 6 animals each. Group I to IV served as Vehicle control, OA control, Venlafaxine and dexibuprofen treated groups respectively. Group I recieved I.A. Injection of 50μl of 0.9% normal saline, Group II to IV recieved I.A. Injection of 50μl monosodium iodo acetate (MIA), and the treatment of drugs started on the same day. The animals will be monitored for osteoarthritis parameters and/or pain induced depression on pre-dose day (day 0) and on day 1, 3, 5, 7, 11, 14, 18, 21 and 28 th day.

Keywords: Depression; Dexibuprofen ;MIA; Osteoarthritis; Venlafaxine.

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