Abstract

ANALGESIC ACTIVITY OF VARIOUS EXTRACTS OF LEAVES OF MURRAYA KOENIGII (L) SPRENG

Basanti Brar*, Joginder Singh Duhan and Pankaj Rakha

ABSTRACT

The present study was undertaken to investigate the analgesic activity of various extracts of Murraya koenigii (L.) Spreng. Three types of extracts (petroleum ether extracts, ethanol extracts and water extracts) were prepared from leaves of Murraya koenigii Spreng. Two methods i.e. tail flick and writhing tests were used to study analgesic activity. Pentazocine (10 mg/kg) and aspirin is used as standard drugs. In this work, petroleum ether extract, methanol extract and water extracts were examined at doses of 200 mg/kg and 400 mg/kg. Treatment of rats with all the extracts showed significant analgesic activity. Petroleum ether extract at the dose of 200 mg/kg and 400 mg/kg has significant analgesic activity as compared to ethanol and water extracts with percentage of inhibition 36.33% and 38.18% after 3h treatment by using tail flick method. The mean number of writhing of Murraya koenigii Spreng was found to be 101.41  1.20 and 82.6  1.31 with percentage of inhibition 13.32% and 29.40% at the doses of 200 mg/kg and 400 mg/kg of petroleum ether extract after 1h treatment by writhing method. These results indicate that the extracts of leaves of Murraya koenigii Spreng showed significant analgesic activity through both tests.

Keywords: Analgesic activity, aspirin, rat, tail flick test, writhing test.