Abstract

MICROSPHERES: A PROMISING NOVEL DRUG DELIVERY SYSTEM

P.Bharath *, K.Sruthi, KVM Krishna, T K V Kesava Rao

ABSTRACT

The Non ideal pharmaceutical, pharmacokinetic, and therapeutic properties often combine to reduce the effectiveness of certain compounds. For the vectoring of such compounds to target areas, liposomes, nanoparticles, and microspheres have been suggested. The range of techniques for the preparation of microspheres offers a variety of opportunities to control aspects of drug administration. This approach facilitates accurate delivery of small quantities of potent drugs, reduced drug concentrations at the sites other than the target site and protection of the labile compounds before and after administration, prior to appearance at the site of action. Physicochemical properties of the drug and excipient such as permeability of one in the other, identity of the polymer, degree of crystallinity, inclusion of plasticizers and fillers and thickness of the polymer influences the drug release rate.

Keywords: Microspheres, target site, diffusion, biodegradable, carriers, sustain release.