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TRAMADOL IN THE MANAGEMENT OF PREMATURE EJACULATION: A PRAGMATIC REVIEW
*Niraj Khatri Sapkota and Kailash Chandra Swain
ABSTRACT Premature ejaculation (PE) is the most common sexual disorder affecting 20%-30% of adult men; its etiology still remains idiopathic. Tramadol is a synthetic codeine derivative with a weak agonistic activity on the mu- opioid receptor. It is a unique centrally acting analgesic which also inhibits the neuronal reuptake of nor -adrenaline and serotonin. This review is presented to evaluate efficacy, safety, tolerability, addiction liability on-demand dosing tramadol that is effective in lengthening intra vaginal ejaculation latency time (IELT) in men with varying degrees of PE disorder following treatment. Keywords: Tramadol, analgesic, opioid, IELT, Premature ejaculation. [Download Article] [Download Certifiate] |