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FORMULATION AND EVALUATION OF TASTE MASKED SUSPENSION OF OSELTAMIVIR PHOSPHATE
Mangesh R. Bhalekar*, Ashwini R. Madgulkar, Rahul R. Padalkar, Ashwini H. Sathe
ABSTRACT The present work was aimed to mask the bitter taste of oseltamivir phosphate using ion exchange. Oseltamivir phosphate is an antiviral drug used in the treatment and prophylaxis of both influenza A and influenza. The drug resin complex was prepared by batch method and Indion 234 was selected for ion exchange complex formation. The drug loading process was carried out using various cationic resins and it was optimized using different drug: resin ratio and pH. Resinates were characterized by infrared spectroscopy and thermal analysis. Indion gave the best loading efficiency at drug resin ratio of 1:1; pH had no effect on drug loading. Taste evaluation was carried out by panel method found resinate as tasteless and agreeable. The drug release from resinates in 0.1N HCL was found to be 96% within 45 min. Taste masked suspension of resinate was formulated and evaluated for taste, drug content, viscosity, sedimentation volume, drug release. The efficient taste masking was obtained from drug–resin complex which was formulated as oral suspension in order to increase better patient compliance. Keywords: Oseltamivir phosphate, Indion 234, Taste masking. [Download Article] [Download Certifiate] |