Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF NEW SERIES OF SULFAMETHOXAZOLE DERIVATIVES

Monther Faisal Mahdi*, Rafah Fadhil Al-Smaism, Zainb Mohammed Abd Al-Khaliq

ABSTRACT

Sulfamethoxazole belongs to the sulfonamide group of antibiotic. It was chosen to be the representative of this group due to its widespread use and detection frequency in the aquatic environment. Therefore, new series of sulfa drugs, sulfamethoxazole substituted 5-arylidene -4-thiazolidinone, compounds (M3-8) have been designed and synthesized, these compounds expected to have higher antimicrobial than sulfamethoxazole, due to thiazolidinone derivative pharmacophore. The chemical structure of intermediate and final compounds were characterized and confirmed by measuring their melting points, FT-IR spectroscopy, elementalmicroanalysis (CHNS) andHNMR of final compounds. The preliminary study of antimicrobial activity were done on 3 different strains of bacteria and showed that the final compounds (M3-8) have significant activity compared with standard drug (Sulfamethoxazole).

Keywords: Sulfamethoxazole; thiazolidinones; chalcones; heterocycles ; antimicrobial.