Abstract

BLOCKING OF BETA ADRENERGIC RECEPTORS AS POSSIBLE APPROACH IN CANCER THERAPY

Amal Ajaweed Sulaiman*

ABSTRACT

Later evidence attributed the poor outcome of cancer development and progression to over activity of endogenous stress hormones epinephrine (EP) and nor-epinephrine (NE). Since, activation of β-adrenoceptor (βADRs) signaling pathways, can enhance cell division, proliferation and metastasis. Therefore, blocking of (βADRs) and their downstream events may serve as new strategy to suppress cancer and reduce cell invasion. However the exact impact on cancer cell survival and development still need to be illustrated. Therefore in this article, we try to prospect on the role of beta adrenergic receptor blockers, as a possible future adjuvant therapy that may lend pharmacological supports for conventional treatments to achieve better management of cancer.

Keywords: Cancer, stress hormones, beta blockers, adrenaline.