Abstract

HEPATOPROTECTIVE ACTIVITY OF CAJANUS CAJAN IN SODIUM FLUORIDE TREATED SWISS ALBINO (BALB/C) MICE

D.Kayathri*, R.V. Kalaimathi, D. Karthick Rajan, P. Sivamani

ABSTRACT

The present study is an attempt to demonstrate the role of hepatoprotective activity of aqueous extract of Cajanus cajan in sodium fluoride induced hepatotoxicity in mice. Aqueous extract of Cajanus cajan leaves is prepared. Normal control rats receive distilled water only while rats in Sodium fluoride control group receive Sodium fluoride (250ppm) only for 30 days. Another group rats receive Cajanus cajan extract along with 250ppm Sodium fluoride for 30 days. 4th Group rats receive commercial drug (Liv 52) along with 250ppm Sodium fluoride for 15 days. Sodium fluoride produced significant changes in biochemical (increase in AST, ALT, cholesterol, TBAR level), histological (hepatocytes damage). Treatment with C.Cajan extract and Liv 52 significantly prevented the biochemical and histological changes induced by Sodium fluoride. Extract of C.cajan exhibited significant anti oxidant and hepatoprotective activity.

Keywords: Sodium Fluoride, Hepatoprotective activity, Cajanus cajan, BAL B/C Mice.