Abstract

SYNTHESIS AND IN VITRO ANTI-BREAST CANCER EVALUATION OF SOME NOVEL 1, 3-THIAZINES AND THIAZOLONE DERIVATIVES INCORPORATING PYRAZOLE MOIETY

Abdou O. Abdelhamid*, Ahmad S. Shawali, Sobhi M. Gomha and Waleed A.M.A. El-Enany

ABSTRACT

New series of novel functionalized 1,3-thiazines containing pyrazole moiety was synthesized using 4-acetylpyrazole as a precursor. The structures of the compounds prepared were confirmed by both spectral and elemental analyses and by alternate synthesis. The mechanisms of the reactions studied were also discussed. The newly synthesized compounds have been evaluated for their antitumor activity against human breast carcinoma (MCF-7) cell lines and the results showed good inhibition effects comparable to Doxorubicin, used as a standard.

Keywords: Pyrazoles, Thiosemicarbazones, 1,3-Thiazines, Thiazolone, Anticancer activity.