Abstract

ABHRAK BHASMA AND SiO2 CONTEMPLATED LEVELS OF SERUM CHOLESTEROL, TRIGLYCERIDES AND FREE FATTY ACIDS IN SINGLE DOSE OF CCl4 INTOXICATED RAT

Parashuram Teli, Shashikant Kasabe, Jaywant Jadhav and Aruna Kanase*

ABSTRACT

The serum levels of cholesterol (CHO), triglycerides (TG) and free fatty acids (FFA) were studied to analyse protective effects of abhrak bhasma in graded doses (10, 20, 30 and 40mg/kg body wt given once) against single dose of CCl4 (3.00ml/kg body wt/sc given once) induced hepatotoxicity, administering (PO) it simultaneously. CCl4 administration increased CHO, TG, FFA level significantly. Abhrak bhasma successfully protected the normal levels showing variations in minimum dose requirements viz. CHO-30mg, TG-10mg, FFA-30mg. All the above doses maintained the normal levels. SiO2 treatment showed variance. 10mg and 20mg doses hardly influenced CCl4 induced elevated CHO and 30 and 40mg doses showed marginally high CHO levels than normal. While CCl4 mediated increased FFA levels were hardly influenced by SiO2. Same was true incase of TG where 30 and 40mg dose marginally lowered the TG. Results indicate that tendency of lowering cholesterol is shown by abhrak bhasma and SiO2 but it is more potent incase of abhrak bhasma influence. Though the protective tendency is shared by SiO2, it is not shown by SiO2 high doses. TG and FFA levels were lowered by abhrak bhasma and not by SiO2. Thus silica form in abhrak bhasma is more potent than pure amorphous silica form in SiO2.

Keywords: Abhrak bhasma, SiO2, CHO, TG, FFA.