EVALUATION OF RESPIRATORY PARAMETERS ASSOCIATED WITH PENH USING BAROMETRIC WHOLE-BODY PLETHYSMOGRAPHY
Anuradha Pannu, Ipshita Chattopadhyaya, Randhir Singh, Sumeet Gupta*
Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, Haryana-133203, India.
ABSTRACT
Background: Asthma is chronic, inflammatory disease of the airways
affecting human beings worldwide. The aim of the present study was
to evaluate the effect of anti-asthmatic drugs on Penh associated with
the respiratory parameters using Barometric Whole-body
Plethysmography. Material & Methods: The hannover rats (n=8)
were divided into 6 groups for the study of Penh, Tidal & minute
volume, inspiratory and expiratory flow rate. Theophylline and
carbachol were administered orally and methacholine and clonidine in
aerosol form. Results and discussion: Individual’s respiratory
parameters showed statistically significant (p
Keywords: Asthma, Penh, Respiratory parameters, Whole-body plethysmography.
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