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Abstract

EVALUATION OF RESPIRATORY PARAMETERS ASSOCIATED WITH PENH USING BAROMETRIC WHOLE-BODY PLETHYSMOGRAPHY

Anuradha Pannu, Ipshita Chattopadhyaya, Randhir Singh, Sumeet Gupta*

Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, Ambala, Haryana-133203, India.

ABSTRACT

Background: Asthma is chronic, inflammatory disease of the airways affecting human beings worldwide. The aim of the present study was to evaluate the effect of anti-asthmatic drugs on Penh associated with the respiratory parameters using Barometric Whole-body Plethysmography. Material & Methods: The hannover rats (n=8) were divided into 6 groups for the study of Penh, Tidal & minute volume, inspiratory and expiratory flow rate. Theophylline and carbachol were administered orally and methacholine and clonidine in aerosol form. Results and discussion: Individual’s respiratory parameters showed statistically significant (p

Keywords: Asthma, Penh, Respiratory parameters, Whole-body plethysmography.


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