Abstract

FORMULATION AND INVITRO EVALUATION OF VESICULAR DRUG DELIVERY SYSTEM ENCAPSULATED WITH ZIDOVUDINE

Venkatesh Gavini*, Srinivasa Rao Konijeti and T. Siva Nagaraju

ABSTRACT

Proniosomes are dry formulations of surfactant coated hydrophilic carriers, which can be rehydrated by brief agitation in hot water just before use. Zidovudine is a nucleoside analog reverse transcriptase inhibitor used in the treatment of HIV and AIDS related conditions. It has a shorter half life and high intracellular metabolism which makes it a potential candidate for the development of a sustained release formulation. The objective of present study is to formulate and evaluate vesicular drug delivery system of proniosomes encapsulated with Zidovudine. In the present study six formulations of Proniosomes containing zidovudine were prepared by slurry method using dextrin, nonionic surfactants and cholesterol at variable concentrations. All the formulations were evaluated for their preformulation and post- formulation parameters. The FTIR analysis showed no interaction between the drug and other additives. The post-formulation result of entrapment efficiency was found to be inversely proportional to cholesterol concentration in span 60 formulations and directly proportional to cholesterol concentration in tween 60 formulations. The formed Proniosomes were found to be spherical in shape with uniform drug content in all the formulations. The dissolution profiles of formulations containing high concentration of cholesterol showed better controlled release rate over period of 72 hrs. The kinetic release data best fitted into Peppas model suggesting that drug was released by fickian mechanism indicating that the drug was released by diffusion controlled mechanism.

Keywords: Proniosomes, Zidovudine, Dextrin, Cholesterol, Surfactants.