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COMPUTER AIDED LIGAND DESIGN AND MOLECULAR DOCKING STUDIES ON A SERIES OF PYRIDINE-CHALCONE CONJUGATES AGAINST SELECTED ANTITUBERCULAR DRUG TARGETS
Asst. Prof. A. Kanakaraju,* and Prof. Y. Rajendra Prasad
ABSTRACT Contemporary scenario of drug discovery and development there is an accumulation of diseases through more-complex pathological mechanisms, for which the classic „single target, single drug‟ pattern has moderately or completely ineffective. In these conditions, drugs acting on various targets could offer greater efficacy profiles compared with single-target drugs. Hence in the present research as a part of our ongoing search for new chemical entities as potential antitubercular agents, we could design a series of pyridine-chalcone conjugates to study their inherent mechanism against selected antitubercular drug target by using molecular docking studies. Keywords: Pyridine-chalcone conjugates, antitubercular drug target, molecular docking. [Download Article] [Download Certifiate] |