Abstract

INVESTIGATION OF KONDAGOGU GUM AS A CARRIER TO DEVELOP POLYMERIC BLEND BEADS OF GALANTAMINE HYDROBROMIDE

Valluru Ravi*, T.M. Pramod Kumar and N. Rama Rao

ABSTRACT

Polymeric-blend beads of kondagogu gum with sodium alginate containing drug, galantamine hydrobromide were prepared by varying the concentration of gum and cross linkers viz., AlCl3 and CaCl2. It was found that in comparison between AlCl3 and CaCl2, the particle size, percent yield and drug entrapment efficiency was greater in beads prepared by AlCl3 as a cross linking agent. Formulation SKF5 showed high percent yield which may be attributed for higher concentration of kondagogu gum. SEM photographs for the prepared formulation indicated that the beads were having smooth and crack-free surface. FTIR and DSC spectra indicated that galantamine hydrobromide drug has not undergone any chemical interaction with the polymers and excipients used. In vitro drug release data indicated that formulations SKF3, SKF5 and SKF6 showed a release of about 96, 93 and 90% at the end of 12 h indicating their suitability for showing a 12 h release profile. Mathematical model fitting indicated that the best-fit model for the formulations was peppas and the release of drug from the polymer matrix followed super case-II transport. Formulation SKF5 was found to be ideal and when subjected for stability studies showed that the drug was stable.

Keywords: Kondagogu gum, beads, sodium alginate, galantamine hydrobromide.