Abstract

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL FUSED RING PYRIDINE MORPHOLINE BENZENE SULPHONAMIDE DERIVATIVES

Loganathan Velupillai*, Prashant P. Dixit, M. S. Shingare, D. V. Mane, Choudhari B. R.

ABSTRACT

A novel series of seven novel 4-(2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-ylsulfonyl)aniline derivatives (4II e – 4II k) have been synthesized from commercially available 2-Amino-3-Hdroxy Pyridine as a starting material. High yield and high purity indicates lack of side reaction and by product. The chemical structures of the synthesized compounds were confirmed by means of 1HNMR and mass spectral data. The synthesized compounds were then examined for their antibacterial and antifungal activities. Some of them were found to possess good activity.

Keywords: Fused Ring, Morpholine, Benzenesulphonamide, Antibacterial, Antifungal Activity.