Abstract

IMPACT OF INCLUSION COMPLEX FORMATION ON ANTIOXIDANT ACTIVITY OF SOME 4-ARYLIDENAMINO-5-PHENYL-4H-1, 2, 4-TRIAZOLE-3-THIOLS

*Sunakar Panda, Sashikanta Nayak, Pramod Kumar Das

ABSTRACT

Inclusion complexes of some 4-arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols have been prepared with β-cyclodextrin. The formation of complexes has been ascertained by studying the changes in physical and spectral properties of the compounds before and after their formation. The thermodynamic stability constant and free energy of activation have been determined to know the stability of inclusion complexes and type of host-guest relation. Finally, the compounds and their inclusion complexes are screened for antioxidant activities. It is found that inclusion complexes of the newly synthesized compounds have appreciable stability in the cavity of β-cyclodextrin and inclusion complex formation increases their antioxidant activities significantly as compared to naked compound.

Keywords: Triazole-3-thiol, Inclusion complex. Antioxidant activity.