Abstract

FORMULATION AND INVITRO EVALUATION OF METFORMIN HCL SUSTAINED RELEASE MATRIX TABLET USING NATURAL POLYSACCHARIDE

Dharmendra Solanki٭¹, Surendra kumar Jain², Sujata Mahapatra³

ABSTRACT

The aim of this investigation was to develop and optimize Metformin HCl matrix tablets for sustained release application. The sustained release matrix tablet of Metformin Hcl was prepared by wet granulation technique using Jackfruit seed polysaccharide. The prepared tablet was evaluated for different parameter which shows JSP release retardant material for sustained drug delivery. Present study shows The polysaccharides obtained after extraction was creamish white in colour (Jackfruit), The viscosity were found to be, 12.59 cp for jackfruit polysaccharide. The pH was found to be 6.4 for jackfruit polysaccharide. The angle of repose for all the formulations blend was found to be in the range from 20-25 it indicate well to passable flow of granules. Compressibility index was found between 8.53 % and 21.19 % indicating the powder blend has the excellent to good flow property for compression. The measured hardness of tablets of each batch ranged between 4.01 to 5.98 kg/cm2. The % friability was less than 1% in all the Formulations .The drug content for all the formulated tablets was found to 98 % to 99.79 % of Metformin HCL. Formulation JF-1 shows up to 92% of drug release in 720 min. whereas formulation JF-2 shows 89 % of drug release in 720 min. which shows Formulation JF-1 and JF-2 shows the sustained release of drug up to extended time. In FTIR identical principle peaks were observed in all the cases, Hence it shall be confirmed that interactions do not exist between the drug and polymer.

Keywords: Metformin, Matrix tablet, Sustained Release, Jackfruit Polysaccharide.