Abstract

OXIDATIVE SPECTROPHOTOMETRIC DETERMINATION OF DRUGS USING KMnO4 AND METHYL ORANGE AS DYE.

Tirupathi Baddenapalli and Venkateshwarlu Gandu*

ABSTRACT

Simple, sensitive and selective methods are developed for the spectrophotometric determination of drugs, viz., sumatriptan succinate, Olmesartan medoxomil, Levofloxacin, Dobutamine hydrochloride and Duloxetine hydrochloride, based on their reactivity towards KMnO4. The methods involve the addition of excess KMnO4 of known concentration in the presence of 2M H2SO4, reactants are allowed to react and the unreacted KMnO4 is estimated by the measurement in the decrease in the absorbance of the Methyl Orange dye (λmax 507nm). These methods have been applied for the determination of drugs in their pure form as well as in tablet formulations. These methods have been validated in terms of guidelines of ICH.

Keywords: Spectrophotometry, Drugs, KMnO4, Methyl Orange, Quantification, Validation.