Abstract

SOLID LIPID NANOPARTICLES AS CARRIERS IN DRUG DELIVERY SYSTEM

Anadi Tiwari, Surabhi Rashi* and Sonia Anand

ABSTRACT

At the beginning of the nineties solid lipid nanoparticles (SLN) have been introduced as a novel nanoparticulate delivery system produced from solid lipids. Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. SLNs were introduced to overcome problems of polymeric nanoparticles. They are colloidal particles of 1-1000 nm size. Recently, increasing attention has been focused on these SLN as drug carriers for incorporating hydrophilic or lipophilic drugs. SLNs were prepared by hot homogenization followed by ultrasonication. It gives controlled or sustained release and if surface modified then target release also. A number of route of administrations such as topical, oral, parentral, nasal and pulmonary have been proposed for the delivery of SLNs. It can be used to improve the bioavailability of drugs. In this review SLNs are discussed in terms of their advantages, synthesis and characterization.

Keywords: Solid lipid nanoparticles, drug delivery, preparation, characterization.