Abstract

BIO MARKERS IN WOMEN WITH BREAST CANCER: II HORMONES, CALCIUM, VIT D, GLUCOSE AND IGF PREDICTIVE VALUE

Amina Hamed Alobaidi, Arzu Jalaly, Abdulghani Mohamed Alsamarai*, Hamid Hindi Sarhan.

ABSTRACT

Background: Breast cancer is the most commonly diagnosed cancer among Iraqi women. Many factors proposed as risk factor for the development of breast cancer. Aim: To examine the relationship between some circulating markers and breast cancer risk. Patients and Methods: 100 women with breast cancer and 100 healthy controls were included in the study. All patients and control groups serum samples were subjected for determination of progesterone receptor, estrogene receptor, PTH, insuline growth factor, Vit D, prolactin, progesterone, estrogen, HBA1C , Blood sugar and calcium. Results: Serum mean values of prolactin, progesterone receptor, estrogene receptor, glucose, HBA1C, and calcium were significantly higher in women with breast cancer than in controls. While circulating estrogene, progesterone, IGF-1, PTH, and vit D mean values were significantly lower in breast cancer than in controls. OR confirm the association between the tested markers and breast cancer. Conclusion: This study indicated a significant association between breast cancer and serum levels of prolactin, progesterone, estrogene, progesterone receptor, estrogene receptor , sugar, HBA1C, insuline growth factor , Ca+2 , Vit. D and PTH, However, AUC of ROC indicated the low predictive value of estrogene and progesterone.

Keywords: Progesterone Receptor, Estrogen Receptor, PTH, Insuline Growth Factor, Vit D, prolactin, progesterone, estrogen, HBA1C, Blood sugar and calcium, breast cancer.