Abstract

ISOLATION AND STRUCTURAL DETERMINATION OF COMPOUND AM-4 FROM THE STEMBARK OF Annona muricata Linn

Dr. Shubhra Singh*

ABSTRACT

Annona muricata Linn, belongs to the family Annonaceae. Oil from seeds of some plants may be used for the production of edible oils and soaps. Finally, many members of this family are used in folk medicines for various purposes. Annona muricata roots are used as anti-spasmodic, parasiticidal. Flower and flower buds as a bechic. The unripe fruits is useful as anti-scorbutic. Seeda are useful as fish-poison, insecticidal and astringent. The compounds that are isolated from A. muricata are Anomuricine, Anomurine, Coclaurine, Reticuline, Coreximine, Stepharine, Atherosperminine, Anonaine and Liriodenine. AM-4 was obtained as waxy solid, m.p 87-890C, [a]D23 + 11.00 (c=0.4, MeOH), from the fraction slightly more polar than squamocin. AM-4, C37H66O8, (FAB-MS : m/z 639 (M+H)+), indicated the presence of a,b- unsaturated g- lactone and hydroxyl groups. AM-4 was identified as Squamostatin-A on the basis of detailed spectroscopic analysis and comparison with authentic sample.

Keywords: Annona muricata, Squamostatin, Squamocin, 1H-NMR spectrum, Annonaceae.