Abstract

EFFLUX TRANSPORTERS: ROLE IN DRUG BIOAVAILABILITY, EFFLUX AND RESISTANCE

Gurramanjot Kaur*, Akashdeep singh, Amardeep Kaur, Arvinder Kaur, Jasdeep Kaur, Harpreet Kaur, Sandhya goyal

ABSTRACT

ABC transporter proteins are the receptors which regulate the entry of lipophillic drugs and xenobiotics through cell membrane. It does not allow xenobiotics to accumulate at site of action. So there is need to study about ABC transporters in detail so that we may enhance the transportation of drug by inhibiting these transporter receptor.

Keywords: Xenobiotics, ABC transporters, P-glycoprotein.