Abstract

ANTIBACTERIAL ACTIVITIES OF NEW SCHIFF BASE METAL COMPLEXES SYNTHESISED FROM 2-HYDROXY-1- NAPHTHALDEHYDE AND 5-AMINO -1-NAPHTHOL

P. Subramanian1* and M. Sakunthala2

ABSTRACT

The new Schiff base ligand and its symmetrical tetradentate metal complexes were screened for their antibacterial activities against one gram positive bacteria and two gram negative bacteria (Staphylococcus aureus, Klebsiela pneumoniae and Eschrichia coli) and have been carried out using nutrient agar as medium. The zones of inhibition of the synthesized compounds are compared with the free ligand, the standard streptomycin and have been discussed. The antibacterial activity is dependent on the molecular structure of the compound, the solvent used and the bacterial strain under consideration. All the new complexes have higher activity than the free ligand and the standard. The symmetrical tetradentate Schiff base complexes were prepared by the reaction of the Schiff base ligand derived from 2-hydroxy-1-naphthaldehyde and 5-amino-1-naphthol (1:1 molar ratio) and the metal salt in 2:1 molar ratio. The ligand and its complexes with Cu(II), Zn(II), Ni(II) and Mn(II) ions were characterized by elemental analysis, infrared and electronic spectra as well as conductivity measurements.

Keywords: Antibacterial activity, 2-hydroxy-1-naphthaldehyde, 5-amino-1-naphthol, Schiff Base.