Abstract

NANOSUSPENSION TECHNOLOGY FOR POORLY SOLUBLE DRUGS - A REVIEW

Mounica Velmula*, Prathibha Pavuluri, S.Rajashekar, Dr.V.Uma Maheswara Rao

ABSTRACT

Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Many of the newly developed drugs are poorly soluble and they create major problems during formulation and shows poor bioavailability. The problem is even more complex for drugs which belong to BCS Class II category. To overcome these problems nanotechnology is used to improve the solubility as well as bioavailability of poorly soluble drugs. Nanosuspensions are a part of Nanotechnology. Nanosuspensions are defined as the submicron colloidal dispersions of pharmaceutical active ingredient particles in a liquid phase, size below 1ƒÊm (10-9 meters), without any matrix material which are stabilized by surfactants and polymers. Preparation of nanosuspension is simple and applicable to all drugs which are aqueous insoleble. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion]solvent evaporation, melt emulsification method and super critical fluid techniques. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels.

Keywords: Bioavailability, colloidal dispersion, drug delivery, nanosuspension, solubility.