Abstract

VILDAGLIPTIN INDUCED FIXED DRUG ERUPTION- A CASE STUDY

Mr. Noel M Isaac, Ms. Mini Johnson Christudas, Ms Sowjanya Kanumilli, Dr. Justin Kurian, Dr. M Ramesh*

ABSTRACT

Drug induced eruptions are reported to be the most common cause of cutaneous disorders encountered by the dermatologist. A Fixed drug eruption (FDE) is one among the cutaneous adverse reaction that is solely caused by the exogenous administration of drugs or chemicals and is usually characterized by recurrent site specific lesions whenever the offending drug is taken. In our study, FDE was first observed to appear on the patients left forearm after 7 weeks of initiation with stable dose of vildagliptin at 50mg/day and the site specific lesions healed gradually without the need of any pharmacological intervention upon its withdrawal. When causality assessment using Naranjo’s algorithm was made, vildagliptin was found as a probable causative agent in inducing FDE.

Keywords: Cutaneous adverse reactions, Fixed drug eruptions, Vildagliptin.