Abstract

MICROWAVE ASSISTED SYNTHESIS OF 4-SUBSTITUTED POLYHYDROXLIDENE-2-PHENYL OXAZOLIDINE-5-ONES

*B.Anupama, Knv Chenchu Lakshmi, J.Naga Sindhura.

ABSTRACT

A series of new oxazolidines were prepared by Erlenmeyer condensation of hippuric acid and polyhydroxylated aldehydes or ketones. The synthesized oxazolidines derivatives were characterised by means of IR,1H-NMR,13C-NMR spectral data.All the compounds were checked for their bioactive score using online software that is molinspiration programme and also tested for Cytochrome P-450 inhibition using ochem series.These compounds are having better bioactive score against enzyme and protease inhibition. These compounds were evaluated for their biological activities like antibacterial and antifungal activity .The compounds are more sensitive towards gram positive than gram negative bacteria . They possess significant activities when compared with standard fluconazole.

Keywords: oxazolidines, synthesis, antimicrobial, antifungal activity.