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TUNABLE SYNTHESIS OF GELATIN NANOPARTICLES EMPLOYING SOPHOROLIPID AND PLANT EXTRACT, A PROMISING DRUG CARRIER
Zeinab Ghasemishahrestani, Mihir Mehta, Priti Darne, Aishwarya Yadav, Asmita Prabhune*, Suvidya Ranade*.
ABSTRACT
Biodegradable polymer nanoparticles are being explored as drug delivery vehicle for various diseases till date. We report for the first time the green synthesis of tunable gelatin nanoparticles by nanoemulsion method using Cassia fistula leaf extract and Sophorolipids synthesized by a non-pathogenic yeast Candida bombicola ATCC 22214 a glycolipid biosurfactant. Sophorolipid and plant extract helped in compaction and reduction in size of gelatin nanoparticles with effective loading of Quercetin so as to get spherical nanoparticles with size ranging between 20-60 nm. SEM, TEM and DLS results are in agreement for the size of nanoparticles. Sustained Keywords: Biodegradable, Gelatin, Cassia fistula, Sophorolipids, Quercetin, Cytotoxicity. [Download Article] [Download Certifiate] |