Abstract

TO STUDY EFFECT OF VARIABLES AND PROCESS PARAMETERS ON ENGINEERING OF SERTACONAZOLE LOADED SOLID LIPID NANOPARTICLES: OPTIMIZATION AND FORMULATION APPROACH

Anagha Baviskar*, Shivanand Hiremath and N. Devanna

ABSTRACT

This study is about fabrication and evaluation of sertaconazole loaded solid lipid nanoparticles (SERT-SLN) made up from natural resources. With the aim to reduce the symptomatic effects of superficial fungal infection, to overcome the side effects of sertaconazole and to improve the topical drug delivery to lower skin strata, we have formulated SERT-SLN. The technique used for fabrication of SERT-SLN is very simple, reproducible and the formulation components are novel, nontoxic and enhanced pharmacological effects. Taguchi L9 orthogonal design has been employed to investigate the effects of various components on the formulation of solid lipid nanoparticles. Fabricated SERT-SLN were evaluated for DSC, TEM and XRD study revealing sertaconazole and lipid in crystalline form and after formulation, sertaconazole get encapsulated inside the lipid matrix and exists as amorphous in nature. Aloe vera gel study showed excellent rheological property and spreadability, suitable for topical drug release. Hydrating effect enhanced the penetration of SLN into deeper skin strata for prolonged drug release. Incorporation of SLN aloe vera gel with natural lipid, surfactants and organic solvent suggests additive effect on skin penetration and skin repair mechanism. SERT-SLNs were found to be stable and compatible for long period of time.

Keywords: Solid lipid nanoparticles, Taguchi L9 orthogonal array design, superficial fungal infection, Response surface methodology, Natural lipid and surfactant.