Abstract

EVALUATION OF HYPOLIPIDEMIC EFFECTS OF THE ETHANOLIC EXTRACT OF CAESALPINIA BONDUC (L.) IN TRITON WR-1339 INDUCED HYPERLIPIDEMIC RATS

Pankaj G. Jain* and Sanjay J. Surana

ABSTRACT

Objective: To investigate the hypolipidemic activity of the ethanolic fruit extract of Caesalpinia bonduc in Triton WR 1339 induced hyperlipidemic Sprague Dawley rats. Methods: Triton WR 1339 was used to induce hyperlipidemia in experimental rats. 70 % ethanolic fruit extract of C. bonduc was given orally at three different doses of 200 mg/kg, 400 mg/kg and 600 mg/kg to determine hypolipidemic activity. These hypolipidemic effects were compared with a vehicle control group. Simvastatin was used as standard reference drug. Results: Ethanolic fruit extract at its increasing doses significantly reduced plasma cholesterol, triglyceride, VLDL and LDL cholesterol levels as compared to the vehicle control group. Atherogenic index remarkably decreased in extract treated rats compared to vehicle control.HDL cholesterol level was significantly increased in extract treated group. Conclusions: These results suggest that ethanolic fruit extract of C. bonduc possess significant hypolipidemic activity.

Keywords: Hypolipidemic activity, Caesalpinia bonduc, Triton solution.