Abstract

ROLE OF SELENIUM SUPPLEMENTATION IN THERMAL BURN PATIENTS

Dr. G.Amar Raghu Narayan and *Dr. SK. Deepthi

ABSTRACT

Burns represent a major health problem worldwide with high mortality and morbidity and economic loss even with small burns. The profound oxidative stress that occurs following injury results in significant depletion of many endogenous antioxidants (Vitamin C,E, selenium). Increasing evidence suggests antioxidant supplementation reduces infectious complication and organ dysfunction following injury and hemorrhagic shock. The objective of this study was to evaluate the role of supplementation of selenium Vitamin E, GSPX in burn patient and to compare the difference in the healing of burn wounds before and after supplementation. There was significant increase in serum selenium and vitamin E levels after supplementation on day 7. No significant increase was seen in GSPX levels after supplementation along with vitamin E was associated with higher circulating plasma and skin tissue content of selenium and improved antioxidant status. These changes were associated with improved clinical outcome, including lower infectious rate and decreased hospital stay.

Keywords: critical illness, burns, supplementation, GSPX (Glutathione peroxidase) vitamin E, Selenium.