Abstract

DEVELOPMENT AND INVITRO EVALUATION OF LOVASTATIN TABLETS USING FLOATING DRUG DELIVERY SYSTEM

Sandeepthi Bommakanti*, Lingaraj S. Danki, G. Sridhar Babu, D. Vijay Kumar, Md. Sharfuddin, N Y Dileep Kumar.

ABSTRACT

the present study, development of Gastroretentive Drug Delivery System (GRDDS) of Lovastatin, an Antihyperlipidemic drug was designed to increase the gastric residence time, thus prolonging the drug release. Wet granulation method has been employed to prepare GRDDS of Lovastatin with hydroxy propyl methyl cellulose (HPMC) of different viscosity grades (4,000cps, 15,000cps, 100,000cps) and other polymers like Carbopol 934P and Chitosan, each with different drug to polymer ratios. The prepared GRDDS were evaluated for various parameters. The drug polymer ratio, various polymers, different diluents and gas generating agents were found to influence the drug release and floating properties of the GRDDS. The floating properties and drug release characteristics were determined for the prepared GRDDS in 20% of 0.2% (w/v) SLS in 0.1 N HCl dissolution media. All the GRDDS formulations showed good In vitro floating properties with an optimum concentration of gas generating agents, sodium bicarbonate and citric acid. It was found that HPMC (K4M, K15M, and K100M), Carbopol 934P and Chitosan had significant impact on the drug release from the prepared GRDDS. Among the different types of polymers employed, when used along with lactose as diluent, was found to be beneficial in improving the drug release rate and floating properties. The drug polymer interaction studies indicated that there was no interaction. The short term stability study depicted that there was no much difference observed.

Keywords: Lovastatin, Gastroretentive Drug Delivery System, HPMC, Carbopol 934P, Chitosan, Sodium lauryl sulphate.