Abstract

HISTOPATHOLOGICAL STUDIES OF AQUEOUS METHANOLIC LEAF AND BARK EXTRACT OF DOLICHANDRONE ATROVIRENS

Saminathan Kayarohanam*, S. Kavimani

ABSTRACT

The present study was aimed to investigate the complications of untreated diabetes on histomorphology of rats. Diabetes mellitus was experimentally induced in male wister rats by administration of streptozotocin. The establishment of diabetes mellitus was confirmed by fasting blood glucose levels. The animal was divided in to five groups. Group group one rats served as healthy controls that received vehicle in a similar manner other four is treated by the aqueous methanolic leaf and bark extract Dolichandrone atrovirens given in the dose of 200 mg/kg, p.o and 400 mg/kg, p.o. For histomorphological study of different organs, 50% of the animals were sacrificed after 14 days. The blood glucose level of diabetic rats was raised significantly throughout the experimental period. Further, histomorphological alterations were registered in kidneys and liver. The results show gross examination of liver and kidney did not show any abnormalities. It is clear from these results that Dolichandrone atrovirens leaves extract and bark is free from hepatic and renal toxicity.

Keywords: .