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SYNTHESIS, CHARACTERISATION, ANTIMICROBIAL EVALUATION OF 2-OXO-AZETIDINE DERIVATIVE
S.Ramachandran*, M.A.Rizwanullah, Santhiya T, Senthil Kumar.D, Sandeep Kumar, Dr.N.Deepa and Dr. R.Sundhararajan
ABSTRACT A new series of N-(3-chloro-2-oxo-4-phenylazetidin-1-yl) isonicotinamide was synthesized by the reaction of schiff base (isonicotinohydrazide and benzaldehyde) with chloroacetyl chloride respectively. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. . The synthesized compounds showed no antibacterial activity against Staphylococcus aureus and Escherichia coli. Keywords: Antibacterial, Aromatic aldehyde, Isoniazid, Chloroacetyl chloride,Schiff Base, Azetidinone. [Download Article] [Download Certifiate] |