Abstract

DIFFERENT ANALYTICAL TECHNIQUES FOR QUANTITATIVE ANALYSIS OF OMEPRAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

S. Sirish Chandra*, T. Chandra Mohan, G.Nagasowjanya, A. Ajitha,
V. Uma Maheshwara Rao

ABSTRACT

Omeprazole is a proton pump inhibitor (PPI) and an anti-secretory compound, widely used in treatment of ulcers, heartburn, gastroesophageal reflux, or Zollinger-Ellison syndrome and also given together with antibiotics to treat gastric ulcer caused by infection with Helicobacter pylori. Since many years, varied analytical methods were developed both in dosage forms as well as biological fluids in order to estimate their desired pharmacological action. A few UV spectrometric methods have been reported to estimate the Omeprazole in bulk formulations. Ultimately, different HPLC and LC MS/MS methods explained the importance of the methods while estimation Omeprazole in various biological fluid as well as in routine drug analysis. This review provides clear and short notes on the various analytical technique s employed for determination of Omeprazole in both in vitro and in-vivo conditions.

Keywords: Omeprazole, LC MS/MS, Zollinger-Ellison syndrome.