Abstract

THE STUDY OF HEMODYNAMIC CHANGES OF PATIENTS UNDER GENERAL ANESTHESIA WITH DIFFERENT RATES OF INJECTION OF REVERSE

Sohrab Kochaki, Dr. Kaveh Behaeen, Dr. Kamran Mahmodi, Mostafa Fatahi*, Hossein Rahmani

ABSTRACT

Background and Purpose: Neostigmine is used to reverse the neuromuscular block, and Atropine is used to antagonize the muscarinic effects of Neostigmine. This study aims to investigate hemodynamic changes of patient under general anesthesia with different rates of reverse injection. Methods: This applied study was performed on 64 ASA1 patients under general anesthesia. In both group, premedication was done by Midazolam, Fentanyl and induction was done by thiopental and Atracurium. Then, the patient was reversed by mixture of Neostigmine and Atropine. The injected rate of reverse in group A was 5s and in group B was 15s. One minute before injection of reverse and in minutes 1, 2, 3, 4, 5, 10, 15, 20, 25, and 30 after injection of reverse, hemodynamic changes were recorded in both groups. Results: Findings show that group A had initial increase in heart rate till third minute after injection of the reverse and then heart rate changes descended along with fluctuations. In group B, the initial increase in heart rate continued to 3 minutes after reverse and heart rate changes had steady descent and other variables of hemodynamic changes didn't have significant differences. Conclusion: Based on these results, it is recommended to have a better stability of the hemodynamic changes after injection of reverse, it should be injected within 15 seconds.

Keywords: Neostigmine, Atropine, Reverse, Heart rate, Neuromuscular relaxants.