Abstract

EFFICACY OF METHANOL LEAF EXTRACT OF Pimento dioica (MYRTACEA) ON THE BLOOD GLUCOSE LEVEL AND LIPID PROFILE OF STREPTOZOTOCIN INDUCED DIABETIC ALBINO RATS

K. Yoga Lakshmi* and J. Vaidehi

ABSTRACT

The present study was designed to investigate the antidiabetic andantihyperlipidemic activity of the methanolic extract of the leaves ofPimento diocia in streptozotocin (STZ) induced diabetic rats. Diabeteswas induced in male albino wistar rats by single intraperitonealinjection of STZ. Three days after STZ induction, the diabetic ratswere treated orally with P.dioica at the doses of 75mg/kg and 150mg/kg of body weight daily for 45 days. Glibenclamide (0.6mg/kg ofbody weight) was used as reference drug. Blood glucose estimationwas performed every week of the study. At the end of the study period,animals were sacrificed for the measurement of fasting blood glucose,total cholesterol (TC), triglyceride (TG), high density lipoprotein(HDL), low density lipoprotein (LDL) and very low density lipoprotein(VLDL). Significant reduction (P<0.005) in fasting blood glucose levels was observed withincreasing treatment durations. Thus the present study suggested significant antidiabetic andantihyperlipidemic potential in the methanolic leaf extracts of P. dioica.

Keywords: Antidiabetic, antihyperlipidemic, Pimento dioica, glibenclamide.