Abstract

NANOCOCHLEATES: A NOVEL APPROACH

Ganesh Jagdale*, Shubhangi Warad

Dusarbid, Sindkhed Raja, Buldhana, India.

ABSTRACT

Nanotechnology is a multidisciplinary field, convergence of basic sciences and applied disciplines like biophysics, molecular biology, and bioengineering. It has created powerful impact in various fields of medicine including cardiology, ophthalmology, endocrinology, oncology, pulmology, immunology etc., and to highly specialized areas like gene delivery, brain targeting, tumor targeting, and oral vaccine formulations. Size reduction is a fundamental unit operation having important applications in pharmacy. It helps in improving solubility and bioavailability, reducing toxicity, enhancing release and providing better formulation opportunities for drugs. In most of the cases, size reduction is limited to micron size range, for example, various pharmaceutical dosage forms like powder, emulsion, suspension etc. Drugs in the nanometer size range enhance performance in a variety of dosage forms. The word ‘nano’ is derived from Latin word, which means dwarf. Nano size refers to one thousand millionth of a particular unit thus nanometer is one thousand millionth of a metre (i.e. 1nm = 10 -9 m). Nanotechnology has shown tremendous progress in these fields. However, biomedical and pharmaceutical fields remain yet to be explored.

Keywords: Nanotechnology, phospholipids-cation, Polymeric nanosysytm, Multilayered structure, lipid-based carriers.