Abstract

INDIVIDUAL AND MUTUAL EFFECTS OF APPLIED COMPRESSION FORCE, MIXING TIME AND MANUFACTURING METHOD ON PROPERTIES OF HPMC ORAL MATRICES

Abubakr O. Nur*, Khaled M. Elamin and Zuheir A. Osman

ABSTRACT

This study focus on the influences of individual and joined effects of 3 processing variables, namely, applied compression force, mixing time and manufacturing method on the attributes of hydroxypropyl methylcellulose (HPMC) oral matrices using Ibuprofen as a model drug. 23 full factorial design was selected for the screening purposes where each of the three variable was examined at two possible levels for its individual and joined influence on matrix properties. Though not substantial enough for statistical consideration (p= 0.116), the joined effect of production method, mixing time and hardness on matrix weight variation was found more influential than that of individual variables whereas with drug content property, the joined effect of the three variables appear to have a comparable influence to that of the individual effect of mixing time. Despite the fact that magnitude of the influence of individual effect of compression force on matrix friability was 2-3 times that revealed by individual or mutual effects of other variables, such influence was ignored statistically (p= 0.144). Whilst individual effect of hardness and production method demonstrated to have significant influence on drug release characteristics (p< 0.05), drug release kinetics established to be influenced only by the individual effect of matrix hardness (p

Keywords: Processing variables, HPMC matrices, Individual effects, Mutual effects.