Abstract

‘LYCOPENE CURTAILS CHROMOSOMAL ABERRATIONS AFTER IN VITRO TREATMENT OF BLEOMYCIN TO CULTURED HUMAN LYMPHOCYTES’

Sonal Vashi, Shraddha Saha, Dhruti Mistry, Meonis Pithawala*,
Sumitra Chakraborty

ABSTRACT

In the present study protective effects of lycopene on cultured human lymphocytes against Bleomycin-induced cytogenetic alteration in the form of chromosomal aberrations (CAs) has been observed. Four different cultures were set up. First culture vial was kept untreated, second was treated with lycopene (8μg/ml), third was treated with bleomycin (15μg/ml) and fourth received combined treatment of lycopene (8μg/ml) and bleomycin (15μg/ml). There was significant reduction in the chromosomal aberration frequency, particularly chromosome gaps, chromosome breaks and dicentric chromosomes, in those cultures treated with both lycopene as well as bleomycin when compared to the culture treated alone with bleomycin.

Keywords: Lycopene, Bleomycin, Chromosomal aberrations, Human Lymphocytes.