Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL CHALCONES OF 2-ACETYL-6-METHOXYNAPTHALENE AS POTENTIAL ANTIMICROBIAL AGENTS

D.Vasudha*, Y. Rajendra Prasad, Afzal Basha Shaik, Addipalli Kanaka Raju

ABSTRACT

Chalcones are a group of natural products which posses a wide variety of biological activities. Keeping in mind the diverse array of biological activities associated with chalcones a series of some new chalcones containing different substituents were synthesized by Claisen-Schmidt condensation of 2-acetyl-6-methoxynapthalene with various substituted aromatic and heteroaromatic aldehydes. The synthesized chalcones were purified by recrystallization and column chromatography. The characterization of the purified chalcones was made by IR, 1H NMR and elemental analysis data. These compounds were further subjected for antimicrobial activity studies. When these chalcones were evaluated for antibacterial and antifungal activities, some of them found to possess significant biological activity when compared to standard drugs.

Keywords: Chalcone, Claisen-Schmidt condensation, Antimicrobial activity.