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A NOVEL STRATEGY SYNTHESIS OF ROSUVASTATIN AND THEIR INTERMEDIATES
Premchand B.Patil*, Devanand B.Shinde and Bhata R.Chaudhari
ABSTRACT
The present disclosure provides a novel process for the preparation of intermediates of the statin via Julia-modified olefnation. This can be effectively used for the preparation of HMG-CoA reductase inhibitors such as Rosuvastatin and its pharmaceutically acceptable salt, which is suitable for large-scale up, environmentally benign synthesis, costeffective & improved impurity free process is described here by addressing various scales up. Keywords: Statin, Cost-effective, Julia-modified olefnation, Environmentally benign synthesis. [Download Article] [Download Certifiate] |