Abstract

SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL EVALUATION OF CIPROFLOXACIN MACROCYCLIC COPPER (II) COMPLEXES

Richa Kothari* and Anurag Agrawal

ABSTRACT

Ciprofloxacin macrocyclic Cu (II) complexes were synthesized by refluxing of carbohydrazone, ciprofloxacin antibiotic and copper salts. All these synthesized compounds were characterized by various physicochemical techniques like melting point, TLC, elemental analysis, molar conductance analysis, FT-IR, H1NMR, LC-MS, and electronic spectra. The geometry of Cu (II) complexes were octahedral & distorted in nature which is confirmed by the electronic spectra. All compounds were subjected to antimicrobial & antioxidant activity screening using broth serial dilution & H2O2 method. The investigated compounds were tested against various strains of bacteria like E.Coli, S.aureus, Pseudomonas auruginosa and B.subtilus. Copper complexes showed greater antimicrobial activity as compared to standard drug. All compounds showed potent antioxidant activity in the range of 80%-90%.

Keywords: Ciprofloxacin, fluoroquinolone, copper salts, antimicrobial, antioxidant activity.