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SPECTROPHOTOMETRIC DETERMINATION OF AN ANTIDIABETIC DRUG SAROGLITAZAR BULK AND PHARMACEUTICAL FORMULATIONS
Manjusha D. Karad and Dr. V. D. Barhate*
ABSTRACT A new, simple, precise ,sensitive, accurate, and reproducible spectrophotometric method for the determination of saroglitazar in pure and in capsule dosage form is described. The method is based on the oxidation of the drug with alkaline potassium permanganate at room temperature. The absorbance of the green colored manganate ions produced is measured at 600nm. Beer’s law is obeyed in the concentration range of 0.5-3.0 μg/mL for the developed method. The molar absorptivity and sandell sensitivity are found to be 73313.78 L mol-1cm-1and 0.0060 μg/cm2 respectively. The regression equation for saroglitazar was found to be y = 0.152X + 0.021 and the correlation coefficient for the regression line was 0.9995. Different experimental parameters affecting the color development and stability of colored product are carefully studied and optimized. The developed method could be successfully applied to pharmaceutical formulations. The results obtained are in good agreement with those obtained using standard Method. Keywords: Saroglitazar, Spectrophotometric method, KMnO4, LIPAGLYN Marketed formulation. [Download Article] [Download Certifiate] |