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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

Ã¢â‚¬Å“FORMULATION AND EVALUATION OF DICLOFENAC POTASSIUM SUSPENSIONS CONTAINING AN ANTACIDÃ¢â‚¬Â

P.A.Sravanth, Sowbhagya Lakshmi. D, Prasanna. G, Trishya. Y, M. Eswar Gupta

ABSTRACT

The present investigation is concerned with formulation and evaluation of diclofenac Potassium Suspension containing an antacid. Diclofenac potassium is a good Anti-inflammatory drug having a tendency to cause gastric acidity as a side effect. Hence an antacid was included in diclofenac sodium suspension, to counteract the side effect. Four formulations containing diclofenac potassium and aluminium hydroxide were prepared using xanthan gum . They were tested for assay, density, Ease of redispersibility, pH, dissolution rate, sedimentation parameters and taste. Formulation F4 containing xanthan gum as suspending agent was found be the best one with respect to physical stability and drug release. Hence an ideal suspension containing diclofenac potassium and aluminium hydroxide was formulated.

Keywords: Oral suspension, Diclofenac potassium, Aluminum hydroxide, Xanthan gum.

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