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“FORMULATION AND EVALUATION OF DICLOFENAC POTASSIUM SUSPENSIONS CONTAINING AN ANTACIDâ€Â
P.A.Sravanth, Sowbhagya Lakshmi. D, Prasanna. G, Trishya. Y, M. Eswar Gupta
ABSTRACT
The present investigation is concerned with formulation and evaluation of diclofenac Potassium Suspension containing an antacid. Diclofenac potassium is a good Anti-inflammatory drug having a tendency to cause gastric acidity as a side effect. Hence an antacid was included in diclofenac sodium suspension, to counteract the side effect. Four formulations containing diclofenac potassium and aluminium hydroxide were prepared using xanthan gum . They were tested for assay, density, Ease of redispersibility, pH, dissolution rate, sedimentation parameters and taste. Formulation F4 containing xanthan gum as suspending agent was found be the best one with respect to physical stability and drug release. Hence an ideal suspension containing diclofenac potassium and aluminium hydroxide was formulated. Keywords: Oral suspension, Diclofenac potassium, Aluminum hydroxide, Xanthan gum. [Download Article] [Download Certifiate] |