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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROSCOPIC METHOD FOR THE ESTIMATION OF ATENOLOL

P. Madhuri, G. Raveendra Babu*, P. Sambasiva Rao, B. Sivasai Kiran, M. Venkata Kumari

ABSTRACT

A visible spectroscopic method was developed to estimate the amount of atenolol in bulk and its pharmaceutical formulations. Method was based on the formation of colored chromogen (b m reagent). The Î»- max of atenolol was found to be 550nm to both crude and marketed sample, beerâ€™s law was obeyed at the concentrations ranging 2- 10Î¼g/ml. The correlation coefficient was found 0.999. The method was validated for linearity, accuracy, precision and ruggedness. The values of LOD and LOQ for atenolol were found to be 0.148 and 0.449 Î¼g/ml respectively. The mean recovery of the substance was found to be 100.23%. The developed method was found to be simple, sensitive, rapid, precise, accurate and reproducible hence the results obtained of this method will be satisfactory for routine analysis of atenolol.

Keywords: Estimation, Assay, Precision, Validation.

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