Abstract

CATAMENIAL EPILEPSY: FASCINATING INCIDENT IN EPILEPTOLOGY

Amruth Raj Veeduluri, Siddartha Kaskurthy and Vijay Krishna Nidadavolu

ABSTRACT

Catamenial epilepsy may be afflicted by Women. It is defined as changes in seizures severity during exacting phases of the menstrual cycle. Physiological endocrine secretion during the menstrual cycle influences the episode of seizures.Alterations in serum estradiol/ progesterone ratio during a normal reproductive cycle convey increased or decreased risk of seizure occurrence. One-third to one half of women with epilepsy experience catamenial seizure. Awareness of the effects of sex hormones on epilepsy may open novel therapeutic approachesfor women with catamenial seizures pattern. The aim of this article is to reportthe effects of sex hormones on epilepsyand to describe treatment approaches for catamenial epilepsy.The augment in seizure incidence during specific phase of menstrual cycle of the female, is greatly apprehensive of a diagnosis of Catamenial epilepsy.33% of females with refractory seizures in their reproductive age group have this principal condition. Fluctuations in sex harmones can augment liability to seizures in many women. The low progesterone to estrogen ratio is a usually observed biochemical finding during these times. Largemulticenter trials are desirable to recognize the most valuable treatment for women with catamenial epilepsy.

Keywords: Catamenial epilepsy, Epileptology, Menstrual cycle, Seizure occurrences, Sex harmones.