Abstract

STIMULI RESPONSIVE LAYER BY LAYER SELF-ASSEMBLY A NOVEL APPROACHS IN CURRENT DRUG DELIVERY: REVIEW

V.N Gunjkar*, S.L.Patwekar and S.P. Dhage

ABSTRACT

Layer by layer technique is based on the consecutive adsorption of polyanions and polycations via electrostatic interaction. The recent idea of LbL was taken from the work of Langmuir and Blodgett’s. LbL technology at present identified as an environmental friendly technology in fundamental and applied research. This system finds vast area interest due to their multifunctionality and responsiveness to a multitude of stimuli. The present article focus on the various aspects of LbL system mechanism (Electrostatic interaction, Hydrogen bonding, Hydrophobic interaction, Van der waals forces).Advances LbL such as core scarification, ultrasonic encapsulation, dissolution assisted by cosolvation followed by nucleation and various stimuli (Chemical, Physical, Biological) that can be used in delivery of drug formulated through LbL. LbL system have application in related to targeted delivery in cancer therapy, biosensory application, sustain release of drug multifunctional nanocarriers and nanotoxicity. This review covers the various US patents on LbL system.

Keywords: Layer by layer self-assembly, Targeted drug delivery, Biosensory application.